CAPACITY ( 14V445000 )

Dated: MAY 12, 2014 Capacity of Texas (Capacity) is recalling certain model year 2008-2014 terminal tractors trucks equipped with certain Cummins Westport Model ISL G and ISX12 G engines. Condensation in the intake mani…

4C Foods Corp. Voluntarily Recalls 4C Grated Cheese Homestyle Parmesan Because of Salmonella Contamination

4C Foods Corp. is recalling its 6-oz. glass jars of “4C Grated Cheese HomeStyle Parmesan”, UPC 0-41387-32790-8 with code dates BEST BY JUL 21 2016 and JUL 22 2016 due to possible contamination with Salmonella. This recall does not impact any other 4C cheese products. Salmonella is an organism that can cause serious and sometimes fatal infections in young children, elderly people, and others with weakened immune systems.

Regeneca Worldwide, a Division of Vivaceuticals, Inc Expands the Voluntarily Recall of Regeneslim Appetite Control Capsules Due to the Presence of DMAA that May Pose Possible Health Risk

Regeneca Worldwide a division of VivaCeuticals, Inc. Las Vegas, NV is expanding the voluntary nationwide recall of its RegeneSlim appetite control dietary supplement to include lot #823230415, lot #EX0616r 15813, Lot # EX0616R15814 and Lot #11414re5516 because FDA analysis confirmed the presence of DMAA. DMAA is also known as 1,3-dimethylamylamine, methylhexanamine, or geranium extract. DMAA is commonly used as a stimulant, pre-workout, and weight loss ingredient in dietary supplement products.

Kraft Foods Group Voluntarily Recalls Select Varieties of Regular Kraft American Singles Pasteurized Prepared Cheese Product Due to Ingredient Supplier’s Out-of-Standard Storage Temperatures

Kraft Foods Group is voluntarily recalling 7,691 cases of select varieties of regular Kraft American Singles Pasteurized Prepared Cheese Product. A supplier did not store an ingredient used in this product in accordance with Kraft’s temperature standards.

Freshwater harmful algal bloom exposure – an emerging health risk for recreational water users

Freshwater harmful algal bloom exposure – an emerging health risk for recreational water users
Elizabeth D. Hilborn1, Virginia A. Roberts2, Lorraine C. Backer3, Jonathan S. Yoder2, Timothy J. Wade1, Michele C. Hlavsa2
1Environmental Public Health Division, Office of Research and Development, US Environmental Protection Agency, 2Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention
Introduction: Harmful algal blooms (HABs) are increasingly reported among fresh water bodies used for recreation. These blooms, primarily composed of cyanobacteria, are more likely to occur during warm weather and have the potential to produce multiple toxins that adversely impact human and animal health.
Methods: We characterized outbreaks associated with HABs during 2009 – 2010 that were voluntarily reported to the Centers for Disease Control and Prevention by states via the national Waterborne Disease and Outbreak Surveillance System (WBDOSS). Outbreaks consisted of two or more cases of human illness epidemiologically linked to a common HAB exposure in a recreational water setting.
Results: Three states reported 11 outbreaks of human illness associated with freshwater HABs that occurred during summer months of 2009 – 2010. Two of these states had been participating in enhanced HAB surveillance. At least 61 people became ill, 58 sought health care and 2 were hospitalized. No deaths were reported. Among 58 individuals with data to characterize sex or age, 34 were female and 38 were < 19 years of age. Gastrointestinal, respiratory, dermal, eye, ear, general (e.g., fever, headache) and neurologic signs and symptoms were reported. Eight outbreaks included water testing for cyanobacteria toxins; microcystin (n=8), anatoxin-a (n=3), saxitoxin (n=2), and cylindrospermopsin (n=2) were detected within 1 day of the outbreak exposure period. Two outbreaks involved potentially-associated animal illness or death. A review of WBDOSS data yielded three previous freshwater outbreaks associated with HABs; one occurred in 2001, and two occurred in 2004.
Summary: Eleven freshwater HAB-associated outbreaks were reported to WBDOSS for 2009-2010; over 60% (n=34) of ill persons were 19 years of age or younger. This increased number of reports from three states still likely underrepresents the actual public health impact of HAB events nationally. This abstract does not represent EPA policy.

County-level environmental quality and associations with cancer incidence

Cancer has been associated with individual ambient environmental exposures such as PM2.5 and arsenic. However, the role of the overall ambient environment is not well-understood. A novel county-level Environmental Quality Index (EQI) was developed for all U.S. counties (n=3,141) from 2000-2005 data representing five environmental domains: air, water, land, built, and sociodemographic. We linked the EQI to Surveillance, Epidemiology, and End Results Program county-level annual age-adjusted cancer incidence rates for 2006-2010. Sex-stratified random intercept multi-level linear regression models, clustered by state, estimated fixed effects of EQI quintiles on all-site cancer incidence, adjusting for county percentage ever smoked (both sexes) and percentage to have had a mammogram and pap smear (females). Results are reported as incidence rate difference (95% confidence interval) comparing highest quintile/worst environmental quality to lowest/best. All cause cancer was strongly positively associated with EQI in both sexes (males: 32.60(16.28,48.91), females: 30.34(20.47,40.21)). In rural-urban continuum codes (RUCC)-stratified models, ranging from metropolitan urbanized (RUCC1) to rural (RUCC4), we observed positive associations between environmental quality and all-cause mortality for most strata of males (RUCC1: 27.01(11.29, 42.74); RUCC2: 11.29(-18.10,40.67), RUCC3: 25.66(3.85,47.47), RUCC4: -12.12(-50.65,26.42)) and all strata of females (RUCC1: 21.76(8.26,35.26); RUCC2: 2.34(1.62,3.06), RUCC3: 1.77(1.19,2.35), RUCC4: 2.06(0.93,3.19)). Associations in the most urbanized areas were strongest. We also examined the top 3 causes of cancer in each sex. Subtype incidence demonstrated results similar to all-cause cancer. Associations by individual environmental domains will also be presented. These results suggest that environmental exposures can greatly influence cancer risk, and associations vary by urbanicity. This abstract does not necessarily reflect EPA policy.

Evaluation of key events in the mode of action for a carry-over carcinogen in mice

Evaluation of key events in the mode of action for a carry-over carcinogen in mice
Charles E. Wood, April D. Lake, Greg Olson, Michael H. George, Susan D. Hester, Anthony B. DeAngelo
Introduction: Early life environmental exposures are established determinants for adverse health outcomes later in life, although epigenetic drivers for these effects are not currently known. Previously we found that postnatal exposure to dichloroacetic acid (DCA), a common drinking water disinfection byproduct, increased liver tumorigenesis in mice 80 weeks after exposure was stopped. Here we evaluated time course dynamics of key events related to this effect. Experimental Design: The study followed a stop-promotion design in which 28-day old male B6C3F1 mice were given the following treatments in drinking water for up to 93 weeks: deionized water (dH20; control); 3.5 g/l DCA continuously; or 3.5 g/l DCA for 4, 10, 26, or 52 weeks followed by control dH20. Endpoints included liver tumorigenesis, cytotoxicity, and quantitative cell proliferation evaluated across eight time points. Results: Liver tumor incidence was increased in all DCA treatment groups. No group differences in preneoplastic foci were observed. Minimal hepatocellular necrosis was observed with direct DCA exposure, but this effect did not persist after stopping DCA. Prior DCA treatment did not result in increased liver cell proliferation. Conclusion: Transient early adult DCA treatment of relatively short duration (4 weeks) captured the majority of carcinogenic effects resulting from lifetime exposure. This carry-over effect was not associated with sustained cytotoxicity, increased cell proliferation, or preneoplastic lesions. Impact Statement: Key intermediate events resulting from early life DCA exposure do not fit the classical mitogenic or cytotoxic modes of action for non-genotoxic carcinogenesis. Alternative epigenetic mechanisms for this distinctive effect are currently unidentified.

Disclaimer: The research described in this article has been reviewed by the National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and the policies of the Agency.

Dust Storms and Mortality in the United States, 1995-2005

Extreme weather events, such as dust storms, are predicted to become more frequent as the global climate warms through the 21st century. The impact of dust storms on human health has been studied extensively in the context of Asian, Saharan, Arabian, and Australian storms, but there has been little recent population-level epidemiological research on the dust storms in North America. The purpose of the present study is to examine the association between dust storms and mortality in urban metropolitan areas in the United States between 1995 and 2005. Dust storm incidence data, including date and approximate location, are taken from the U.S. National Weather Service storm database. Mortality data for every metropolitan area in the United States were acquired from the National Center for Health Statistics. Conditional logistic regression models were used to study the relationship between mortality and dust storms while accounting for meteorological and air pollutant confounders. Preliminary results based on 421 dust storms occurring in the years 2001-2005 indicate a positive association between dust storms and lagged respiratory mortality.

Disclaimer: This abstract does not necessarily reflect U.S. EPA policy.

EnviroAtlas-Communities: Identifying Nature’s Benefits, Deficits, and Opportunities for Equitable Distribution in Populated Places

Cities, towns, and Tribes rely on clean air, water and other natural resources for economic sustainability and quality of life. Yet natural resources and their benefits are not always fully understood or considered in local decisions. EnviroAtlas is a web-based, easy-to-use mapping tool designed for citizens and planners to assess the status of local and surrounding natural resources and their benefits to society. The Communities component emphasizes connections between ecosystem services and public health and well-being. More than 100 ecosystem services metrics and indicators, socioeconomic data layers, and societal benefits are summarized at the U.S. Census block-group level. Community data can also be used with EnviroAtlas national data, summarized by 12 digit HUC (USGS hydrologic units). These resources help to identify where natural infrastructure meets community demand and where supply falls short. The initial public release of EnviroAtlas features six pilot communities: Durham, NC; Portland, ME; Tampa, FL; Pittsburgh, PA; Milwaukee, WI; and Phoenix, AZ.

Constructing, Quantifying, and Validating an Adverse Outcome Pathway for Vascular Developmental Toxicity

Constructing, Quantifying, and Validating an Adverse Outcome Pathway for Vascular Developmental Toxicity
The adverse outcome pathway (AOP) for embryonic vascular disruption1 leading to a range of adverse prenatal outcomes was recently entered into the AOP wiki and accepted as part of the OECD workplan. This talk will explain how the AOP was built based on molecular initiating events (MIEs) corresponding to genes from critical pathways (hypoxia/growth factor signaling, chemokine networks, extracellular matrix interactions and vessel remodeling/stabilization) with evidence of abnormal embryonic vascular development in the mammalian phenotype browser of the Mouse Genome Informatics database ( ToxCast high throughput screening (HTS) data2 for assays mapping to targets in the AOP were used to prioritize >1000 chemicals for their potential to disrupt vascular development. A subset of these chemicals are being further tested in a wide range of systems. Preliminary results from functional validation of AOP targets, quantification of MIEs and key cellular events3, and compound hazard predictions will be discussed. This abstract does not necessarily reflect EPA policy. This project was funded in whole or in part with Federal funds from the EPA, CSS Research Program, Lockheed-Martin, and NIEHS, NIH under Contract No.HHSN27320140003C.
1Knudsen, T. B. & Kleinstreuer, N. C. Disruption of embryonic vascular development in predictive toxicology. Birth Defects Res C Embryo Today 93, 312-323, doi:10.1002/bdrc.20223 (2011).
2Kavlock, R. et al. Update on EPA’s ToxCast program: providing high throughput decision support tools for chemical risk management. Chemical research in toxicology 25, 1287-1302, doi:10.1021/tx3000939 (2012).
3Kleinstreuer, N. et al. A computational model predicting disruption of blood vessel development. PLoS computational biology 9, e1002996, doi:10.1371/journal.pcbi.1002996 (2013).

Secretary Kerry on U.S. Citizens Detained or Missing in Iran

The Unites States respectfully calls on the Government of the Islamic Republic of Iran to release Amir Hekmati, Saeed Abedini, and Jason Rezaian to their families and work cooperatively with us to find Robert Levinson and bring him home.

Today marks the three-year anniversary of U.S. citizen Amir Hekmati’s detention on false espionage charges while visiting his family in Iran. Mr. Hekmati is the eldest son; he has long been separated from his family and they need him home.

Mr. Levinson went missing in March 2007 on Kish Island. His family has endured years of painful separation and worry. We are immensely concerned about his well-being and whereabouts.

On September 26, Mr. Abedini will have been detained for two years in Iran, on charges related to his religious beliefs. Mrs. Abedini has spoken eloquently about the difficulties her family has faced during this challenging time.

Mr. Rezaian, a reporter for the Washington Post, is being detained in an unknown location. His love of Iran is seen in his reporting – portraits of the generosity and kindness of the Iranian people.

The United States remains committed to returning all of them to their families, friends, and loved ones. We ask the Government of the Islamic Republic of Iran to immediately release Amir Hekmati, Saeed Abedini, and Jason Rezaian and respectfully request the Government of the Islamic Republic of Iran work cooperatively with us to find Mr. Levinson and bring him home.

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Remarks by Angela Simpson Deputy Assistant Secretary National Telecommunications and Information Administration

Education Exchange Kick-Off & Signing Ellijay, Georgia

August 28, 2014

Remarks by Angela Simpson
Deputy Assistant Secretary

National Telecommunications and Information Administration
Education Exchange Kick-Off & Signing
Ellijay, Georgia
August 28, 2014

—As Prepared for Delivery—

Thank you to the North Georgia Network, Parker FiberNet and ETC Communications for inviting me to speak at today’s ceremony to mark the official kick-off of Georgia’s new regional Education Exchange. I am thrilled to be able to share this day and this terrific milestone with you.  My name is Angela Simpson and I am the deputy administrator of the National Telecommunications and Information Administration (NTIA). NTIA, which is part of the U.S. Department of Commerce, is the principal advisor to the President on telecommunications and technology policy issues.

NTIA is honored to have been part of what has made today’s announcement possible through our broadband grant program – the Broadband Technology Opportunities Program. This $4 billion grant program funded by the 2009 Recovery Act, invested in roughly 230 projects nationwide to expand access to and use of high-speed Internet services – including two of the three broadband networks that are joining forces today to launch the new Education Exchange in rural Appalachia.

We awarded a $33.5 million grant to the North Georgia Network to build a 1,100-mile fiber-optic network across 12 counties in the Appalachian foothills of North Georgia. And we awarded a $21.3 million grant to the Appalachian Valley Fiber Network to deploy more than 500 miles of fiber across the lower Appalachian Valley in Northwest Georgia and Eastern Alabama. In 2009, Vice President Biden kicked off announcement of our grants in nearby Dawsonville, so it’s great to be able to come back today and see all the great work done.

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Effect of Exposure to Atmospheric Ultrafine Particles on Production of Free Fatty Acids and Lipid Metabolites in the Mouse Small Intestine

Author Affiliations close
1Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, California, USA; 2Biomedical Engineering, University of Southern California, Los Angeles, California, USA; 3Civil and Environmental Engineering, University of Southern California, Los Angeles, California, USA; 4Department of Bioengineering, School of Engineering and Applied Science, University of California, Los Angeles, California, USA; 5Division of Pediatric Gastroenterology, Departments of Pediatrics and Physiology, University of Alberta, Edmonton, Alberta, Canada
About This Article open

This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.

Citation: Li R, Navab K, Hough G, Daher N, Zhang M, Mittelstein D, Lee K, Pakbin P, Saffari A, Bhetraratana M, Sulaiman D, Beebe T, Wu L, Jen N, Wine E, Tseng CH, Araujo JA, Fogelman A, Sioutas C, Navab M, Hsiai TK. Effect of Exposure to Atmospheric Ultrafine Particles on Production of Free Fatty Acids and Lipid Metabolites in the Mouse Small Intestine. Environ Health Perspect;

Received: 2 May 2013
Accepted: 27 August 2014
Advance Publication: 29 August 2014

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Background and Objective: Exposure to ambient ultrafine particulate matter (UFP) is a well-recognized risk factor for cardiovascular and respiratory diseases. However, little is known about the effects of air pollution on gastrointestinal disorders. We sought to assess whether exposure to ambient ultrafine particles (UFP: diameter < 180 nm) increased free fatty acids and lipid metabolites in the mouse small intestine.

Methods and Results: LDLR-null mice were exposed to filtered air (FA) or UFP collected at an urban Los Angeles site heavily impacted by vehicular emissions for 10 weeks in the presence or absence of D-4F, an apolipoprotein A-I mimetic peptide with anti-oxidant and anti-inflammation properties on a high-fat or normal chow diet. Compared to FA, exposure to UFP significantly increased intestinal hydroxyeicosatetraenoic acids (HETEs), including 15-HETE, 12-HETE, 5-HETE, as well as hydroxyoctadecadienoic acids (HODEs), including 13-HODE and 9-HODE. Arachidonic acid and prostaglandin D2 (PGD2) as well as some of the lysophosphatidic acids (LPA) in the small intestine were also increased in response to UFP exposure. Administration of D-4F significantly reduced UFP-mediated increase in HETES, HODEs, AA, PGD2 and LPA. While exposure to UFP further led to shortened villus length accompanied by prominent macrophage and neutrophil infiltration into the intestinal villi, administration of D-4F mitigated macrophage infiltration.

Conclusions: Exposure to UFP promotes lipid metabolism, villus shortening and inflammatory responses in mouse small intestine, whereas administration of D-4F attenuated these effects. Our findings provide a basis to further assess the mechanisms underlying UFP-mediated lipid metabolism in the digestive system with clinical relevance to gut homeostasis and diseases.